Brisighella is a comune (municipality) in the province of Ravenna, Emilia-Romagna, Italy.
Brisighella borders the following municipalities: Casola Valsenio, Castrocaro Terme e Terra del Sole, Faenza, Forlì, Marradi, Modigliana, Palazzuolo sul Senio, Riolo Terme. It originates from a rocca castle ordered by Maghinardo Pagani and later expanded by Francesco Manfredi, lord of Faenza.
It is the birthplace of Dino Monduzzi (1922—2006), a cardinal of the Roman Catholic Church.
The final part of the novel The Gadfly by Ethel Lilian Voynich (1897) is set in Brisighella. This historical novel, now neglected in England or in the USA, almost unknown in Italy, became very popular in the second half of the 20th century, on the basis of a Marxist reconsideration of its plot, in the USSR, Communist countries in Eastern Europe, Mao Zedong's China, etc.